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The many faces of nitric oxide: cytotoxic, cytoprotective or both
Author(s) -
Wiley J. W.
Publication year - 2007
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2007.00958.x
Subject(s) - nitric oxide , cytotoxic t cell , context (archaeology) , interstitial cell of cajal , motility , mediator , neuroscience , cytoprotection , function (biology) , medicine , chemistry , microbiology and biotechnology , bioinformatics , pharmacology , smooth muscle , biology , oxidative stress , biochemistry , in vitro , paleontology
Nitric oxide (NO) has emerged as a major modulator of cellular function in health and disease. In addition to its well‐known role as a mediator of smooth muscle relaxation, a rapidly developing body of research suggests, paradoxically, that NO can have both cytotoxic and cytoprotective effects. In this issue of Neurogastroenterology and Motility , Choi et al. provide evidence that supports NO has a prosurvival effect on interstitial cells of Cajal in the mouse stomach. The objective of this short review is to place this interesting report in the context of the current literature.