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Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits
Author(s) -
Li L.,
Kong X.,
Liu H.,
Liu C.
Publication year - 2007
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2007.00953.x
Subject(s) - duodenum , oxytocin , stomach , oxytocin receptor , cholecystokinin , endocrinology , medicine , motility , vasopressin , receptor antagonist , antagonist , chemistry , receptor , biology , genetics
The aim of the present study was to investigate the effect of systemic oxytocin (OT) and vasopressin (VP) on the motility of stomach and duodenum. Two plastic balloons made of condom were inserted into stomach and duodenum to monitor the change of mean pressure. Intravenous injection of OT (0.1–0.8 μ g kg −1 ) or VP (0.02–0.08 IU kg −1 ) dose‐dependently increased the stomach and duodenum pressure. Pretreatment of atosiban (1 μ g kg −1 ), the specific OT receptor (OTR) antagonist, attenuated the excitatory effect of OT or VP on the pressure of stomach and duodenum. Pretreatment of V1880 (1 μ g kg −1 ), the specific V1 receptor blocker, did not influence this effect. So we conclude that both of OT and VP injected systemically increased the gastric and duodenum motility via OTR.