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Effects of cyclooxygenase‐2 inhibitor on glucagon‐induced delayed gastric emptying and gastric dysrhythmia in dogs
Author(s) -
Xu J.,
Chen J. D. Z.
Publication year - 2007
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2006.00887.x
Subject(s) - gastric emptying , glucagon , medicine , celecoxib , phenol red , gastroenterology , endocrinology , insulin , stomach , chemistry , chromatography
The objective of this study was to investigate the effects of cyclooxygenase‐2 (COX‐2) inhibitor (celecoxib) on delayed gastric emptying and gastric dysrhythmia induced by glucagon. The study was performed in six healthy female dogs implanted with four pairs of gastric serosal electrodes, and a duodenal fistula for the assessment of gastric emptying. Each dog was studied in three randomized sessions: control, glucagon and COX‐2 inhibitor (celecoxib). Gastric emptying was assessed every 15 min via a duodenal cannula by calculating the amount of collected phenol red which mixed with the test meal and gastric slow waves were recorded at the same time. We found that: (i) glucagon significantly and substantially decreased gastric emptying of liquids (P < 0.001, anova ), increased blood glucose (BG) levels, and induced gastric dysrhythmias. The delayed gastric emptying was correlated with the BG level (R = −0.77, P < 0.001) and (ii) celecoxib improved glucagon‐induced delayed gastric emptying at 30, 45, 60 and 75 min after feeding. Celecoxib did not blocked dysrhythmic action of glucagon (P > 0.05, anova ). In conclusion, glucagon induces delayed gastric emptying partially via COX‐2‐derived prostaglandins. However, COX‐2‐derived prostaglandins are not involved in glucagon‐evoked gastric dysrhythemia. Selective COX‐2 inhibitors may provide a possible therapeutic option for diabetic gastroparesis.