Premium
Mechanosensitive ion channels in interstitial cells of Cajal and smooth muscle of the gastrointestinal tract
Author(s) -
Kraichely R. E.,
Farrugia G.
Publication year - 2007
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2006.00880.x
Subject(s) - mechanosensitive channels , interstitial cell of cajal , ion channel , motility , stretch activated ion channel , smooth muscle , microbiology and biotechnology , gastrointestinal tract , mechanotransduction , membrane potential , electrophysiology , peristalsis , myocyte , chemistry , transient receptor potential channel , biology , neuroscience , biophysics , anatomy , endocrinology , receptor , biochemistry
Normal gastrointestinal (GI) motility is required to mix digestive enzymes and food and to move content along the GI tract. Underlying the complex motor patterns of the gut are electrical events that reflect ion flux across cell membranes. Smooth muscle electrical activity is directly influenced by GI interstitial cells of Cajal, whose rhythmic oscillations in membrane potential in part determine the excitability of GI smooth muscle and its response to neuronal input. Coordinated activity of the ion channels responsible for the conductances that underlie ion flux in both smooth muscle and interstitial cells is a requisite for normal motility. These conductances are regulated by many factors, including mechanical stress. Recent studies have revealed mechanosensitivity at the level of the ion channels, and the mechanosensor within the channel has been identified in many cases. This has led to better comprehension of the role of mechanosensitive conductances in normal physiology and will undoubtedly lead to understanding of the consequences of disturbances in these conductances.