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Gastro‐oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations
Author(s) -
Bredenoord A. J.,
Weusten B. L. A. M.,
Timmer R.,
Smout A. J. P. M.
Publication year - 2006
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2006.00817.x
Subject(s) - reflux , high resolution manometry , medicine , gastroenterology , esophageal sphincter , gastro , sphincter , peristalsis , surgery , disease
Some transient lower oesophageal sphincter relaxations (TLOSRs) are accompanied by gastro‐oesophageal reflux and others are not. We aimed to investigate what factors determine the occurrence and type of reflux during TLOSRs. In 12 healthy subjects prolonged high‐resolution manometry was performed. Reflux was detected using pH‐impedance monitoring. A total of 219 TLOSRs were detected; no differences were observed between the duration of TLOSRs with liquid‐containing reflux (20.2 ± 1.0 s), gas reflux (17.0 ± 1.0 s) and no reflux (19.0 ± 1.0 s). Trans‐sphincteric pressure gradient was similar in TLOSRs with liquid reflux (1.6 ± 0.1 kPa), gas reflux (1.5 ± 0.1 kPa) and no reflux (1.7 ± 0.3 kPa). Prevalence, duration and amplitude of oesophageal pre‐contractions and sphincteric after‐contractions were not different for TLOSRs with and without reflux. The total number of TLOSRs decreased significantly from 8.2 ± 0.8 in the first to 5.7 ± 0.5 in the second and 4.4 ± 0.6 in the third 70‐min recording period. The number of TLOSRs accompanied by liquid‐containing reflux decreased from 4.7 ± 0.9 to 3.0 ± 0.4 to 1.6 ± 0.4, while the numbers of TLOSRs with gas reflux remained unchanged (2.1 ± 0.6–2.1 ± 0.7–2.2 ± 0.6). Besides, time after the meal, no differences were observed in the characteristics of TLOSRs with and without gastro‐oesophageal reflux. We conclude that factors, other than TLOSR characteristics, are important of whether or not a TLOSR is reflux‐related.