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Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans
Author(s) -
De Schepper H.,
Camilleri M.,
Cremonini F.,
FoxxOrenstein A.,
Burton D.
Publication year - 2004
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2004.00533.x
Subject(s) - postprandial , meal , medicine , gastric emptying , liquid diet , volume (thermodynamics) , high resolution manometry , nuclear medicine , gastroenterology , stomach , chemistry , esophagus , physics , quantum mechanics , ethanol , insulin , achalasia , organic chemistry
Aims: To compare gastric volume responses to ingestion of isocaloric liquid or mixed (solid–liquid) meals and document the intra‐ and interindividual reproducibility of gastric volume measurement using single photon emission computed tomography (SPECT) imaging after i.v. 99m Tc‐pertechnetate. Methods: Eight healthy volunteers performed two studies at least 9 months apart. Gastric volumes were measured after a 317 kcal liquid nutrient meal. Within 2 weeks of the second liquid meal study, participants performed a third study, ingesting an isocaloric mixed meal. The order of the mixed and second liquid meals was randomized; Bland–Altman plot displayed data on repeated studies with liquid meal and paired t ‐test compared gastric volumes after mixed or liquid isocaloric meals. Results: Fasting and postprandial gastric volumes associated with the two liquid meals were not significantly different; inter‐ and intra‐individual coefficients of variation were 13 and 13.8%. In response to the mixed meal, there was a lower absolute postprandial volume and lower change in gastric volume over fasting volume compared with the response to the liquid meal ( P = 0.0001). Conclusion: The SPECT measurement of gastric volumes in response to a nutrient liquid meal is reproducible. The magnitude of the volume response is greater after the liquid meal compared with the isocaloric mixed meal.