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Gallbladder motility in vitro in men with gallstones following Billroth II gastric resection
Author(s) -
Maselli Maria Antonietta,
PEZZOLLA F.,
PIEPOLI A. L.,
CARUSO M. L.,
LORUSSO D.
Publication year - 1996
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.1996.tb00239.x
Subject(s) - gallstones , gastroenterology , cholecystokinin , billroth ii , medicine , cholecystectomy , billroth i , gallbladder , gastrectomy , cancer , receptor
Gastric surgery induces an increased incidence of gallstones. To investigate the changes in gallbladder kinetics after gastric resection, 20 male patients were studied: ten patients undergoing cholecystectomy for gallstones developed after Billroth II gastric resection and ten patients undergoing cholecystectomy for cholelithiasis without previous abdominal surgery. Longitudinal strips from the gallbladder wall were suspended in an organ bath and the isometric tension recorded. Dose‐response curves to cholecystokinin‐octapeptide and carbachol were obtained. Half the maximal response to cholecystokinin‐octapeptide was 0.50 ± 0.11 times 10 −7 M in the first group and 1.36 ± 0.37 times 10 −7 m in the second group (P < 0.05). The ED 50 to carbachol was 24.33 ± 2.69 times 10 −7 M in the gastrectomy group and 40.39 ± 5.01 times 10 −7 M in the control group (P < 0.01). There was no significant difference in the maximal contractile response either to cholecystokinin‐octapeptide or carbachol in the two groups. Our study shows an increased gallbladder sensitivity to cholecystokinin‐octapeptide and carbachol in patients with gallstones developed after Billroth II gastric resection.