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Brain noradrenergic systems modulate the ceco‐colonic myoelectric activity in rats *
Author(s) -
BONAZ B.,
MARTIN L.,
BEURRIAND E.,
HOSTEIN J.,
FEUERSTEIN C.
Publication year - 1995
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.1995.tb00215.x
Subject(s) - medicine , endocrinology , central nervous system , electrophysiology , differential effects , chemistry
The role of the brain noradrenergic systems in the control of the ceco‐colonic myoelectric activity was investigated in rats following lesions with intracerebroventricular (icv) or intracisternal (ic) injection of 6‐hydroxydopamine (6‐OHDA). Controls received the vehicle alone. The ceco‐colonic myoelectric activity was recorded 3 weeks later in conscious rats chronically fitted with electrodes. After icv injection of 6‐OHDA, lesions of rostral and caudal (spinal) noradrenergic systems were observed whereas only spinal noradrenergic systems were lesioned after ic injection. This differential pattern of lesions was followed by a differential pattern of ceco‐colonic myoelectric activity. In fasted animals, a significant increase of the long spike burst (LSB) frequency (nb min −1 ) was observed after icv injection of 6‐OHDA whereas no modification was observed after ic injection of the neurotoxic. After a 6‐g pelleted rat diet, a significant increase of the LSB frequency was also observed in the icv lesioned group when compared to controls. No modification of the ceco‐colonic noradrenergic innervation was observed, thus confirming the central selectivity of these lesions. Lesions of central noradrenergic systems modify the LSB frequency in rats; the rostral noradrenergic systems seem to play the major role.