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Effects of a novel intestinal peptide (enterogenin) on the contractile and bioelectric activity of intestinal smooth muscle from the rat and the guinea‐pig
Author(s) -
TRIFFONOV B.,
KRISTEV A.,
ZAPRIANOV G.,
LUKANOV J.,
KOSTADINOVA I.
Publication year - 1992
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.1992.tb00161.x
Subject(s) - guinea pig , motility , smooth muscle , intestinal motility , in vitro , receptor , medicine , endocrinology , chemistry , biology , anatomy , microbiology and biotechnology , biochemistry
The effects of hexapeptide (M.W. 1400) isolated from pig intestine enterocytes and called enterogenin on the motility of gastrointestinal smooth muscle of guinea‐pigs and rats have been studied in vitro. The enhancement of bioelectric and contractile activity observed after treatment with enterogenin is inhibited significantly by the blockers of D 2 receptors, halopehdol and droperidol. On the basis of experiments carried out with Ca 2+ ‐antagonists, enterogenin is shown to have a stimulating effect on the intake of Ca 2+ by smooth muscle cells. This is considered to be the mechanism of enterogenin action on smooth muscles.