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Regulation of Gastric Corpus Tone by the Vagus Nerve in the Ferret
Author(s) -
Grundy D.,
Naseri M. K. Gharib,
Hutson D.
Publication year - 1991
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.1991.tb00044.x
Subject(s) - hexamethonium , vagotomy , vagus nerve , cholinergic , atropine , stimulation , medicine , chemistry , acetylcholine , endocrinology , volume (thermodynamics) , anesthesia , physics , quantum mechanics
The pressure‐volume relationship of the ferret gastric corpus was investigated to quantify the relative contributed of cholinergic and nonadrenergic, noncholinergic (NANC) mechanisms to the volume‐accommodating property of this region. In splanchnectomized animals under control conditions the pressure‐volume relationship of the corpus fitted a linear regression (Y = 0.30X + 0.57). Atropine decreased the magnitude of the pressure rise per unit volume, while after vagotomy this effect was reversed. The magnitude of these pressure changes in individual animals was consistent with reciprocal regulation of cholinergic and NANC pathways. Moreover, after vagotomy the shape of the pressure‐volume curve was altered such that the pressure rise per unit volume was greater at the lower distending volumes. Continuous, low‐frequency electrical vagal stimulation restored the pressure‐volume relationship to that seen prior to vagotomy, an effect abolished by hexamethonium (25 mg/kg). Vasoactive intestinal polypeptide, on the other hand, caused a dose‐related reduction in corpus pressure during the ramp increases in volume comparable to that seen during electrical stimulation but did not restore the shape of the pressure‐volume curve. These data indicate that the action of the vagus may in part be permissive, with the sensitivity of local NANC pathways being modulated by a vagal cholinergic input.