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Protein transport across the cell wall of monoderm Gram‐positive bacteria
Author(s) -
Forster Brian M.,
Marquis Hélène
Publication year - 2012
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2012.08040.x
Subject(s) - biology , cell wall , cell envelope , cytoplasm , bacteria , extracellular , transport protein , microbiology and biotechnology , cell , bacterial outer membrane , cell membrane , membrane protein , bacterial cell structure , gram negative bacteria , membrane transport , membrane transport protein , membrane , biochemistry , escherichia coli , genetics , gene
Summary In monoderm (single‐membrane) Gram‐positive bacteria, the majority of secreted proteins are first translocated across the cytoplasmic membrane into the inner wall zone. For a subset of these proteins, final destination is within the cell envelope as either membrane‐anchored or cell wall‐anchored proteins, whereas another subset of proteins is destined to be transported across the cell wall into the extracellular milieu. Although the cell wall is a porous structure, there is evidence that, for some proteins, transport is a regulated process. This review aims at describing what is known about the mechanisms that regulate the transport of proteins across the cell wall of monoderm Gram‐positive bacteria.