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Regulating the regulator: MicF RNA controls expression of the global regulator Lrp
Author(s) -
Delihas Nicholas
Publication year - 2012
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2012.08030.x
Subject(s) - regulator , biology , master regulator , negative regulator , microbiology and biotechnology , response regulator , expression (computer science) , regulation of gene expression , computational biology , genetics , gene , transcription factor , bacterial protein , signal transduction , computer science , programming language
Summary Studies on the regulatory RNA MicF in Enterobacteriaceae reveal a pivotal role in gene regulation. Multiple target gene mRNAs were identified and, importantly, MicF RNA regulates the expression of the global regulatory gene lrp (Holmqvist et al ., 2012; Corcoran et al ., 2012). Thus MicF RNA is a central factor in a regulatory network that regulates bacterial cell physiology.