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N for AsN – O for StrOcture? A strand–loop–strand motif for prokaryotic O‐glycosylation
Author(s) -
Otzen Daniel
Publication year - 2012
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2012.07972.x
Subject(s) - biology , glycosylation , motif (music) , sequence motif , structural motif , computational biology , n linked glycosylation , genetics , microbiology and biotechnology , biochemistry , gene , glycoprotein , physics , acoustics , glycan
Summary So far, it has not been possible to identify a general sequence motif for O‐glycosylation in bacteria. In this issue, Charbonneau et al . (2012) demonstrate why O‐glycosylation is mediated by a 13‐residue strand–loop–strand motif which is part of a 19‐residue imperfect repeat in the passenger domain of bacterial autotransporters. This motif provides a convenient ‘glycosylation cassette’ and raises intriguing questions about the structural regulation of the glycosylation pathway.