Premium
Cdc42/Rho GTPases in fungi: variations on a common theme
Author(s) -
Harris Steven D.
Publication year - 2011
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2010.07525.x
Subject(s) - biology , cdc42 , gtpase , rac1 , morphogenesis , hypha , microbiology and biotechnology , budding yeast , aspergillus niger , function (biology) , yeast , saccharomyces cerevisiae , botany , genetics , signal transduction , biochemistry , gene
Summary Cdc42/Rho GTPases are universally important regulators of cellular morphogenesis. Whereas their functions are well characterized in budding yeast, they are only beginning to be understood in filamentous fungi. The recent systematic analysis of Cdc42, Rac1 and Rho function in Aspergillus niger provides the first global perspective on their respective roles in hyphal morphogenesis. Surprisingly, the partitioning of these roles between Cdc42 and Rac1 seems to vary even among related fungi. These observations highlight the variable use of a common signalling module in filamentous fungi.