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A new role for coenzyme F 420 in aflatoxin reduction by soil mycobacteria
Author(s) -
Graham David E.
Publication year - 2010
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2010.07358.x
Subject(s) - biology , aflatoxin , aspergillus flavus , cofactor , flavin group , biochemistry , enzyme , mycotoxin , microbiology and biotechnology
Summary Hepatotoxic aflatoxins have found a worthy adversary in two new families of bacterial oxidoreductases. These enzymes use the reduced coenzyme F 420 to initiate the degradation of furanocoumarin compounds, including the major mycotoxin products of Aspergillus flavus . Along with pyridoxal 5′‐phosphate synthases and aryl nitroreductases, these proteins form a large and versatile superfamily of flavin and deazaflavin‐dependent oxidoreductases. F 420 ‐dependent members of this family appear to share a common mechanism of hydride transfer from the reduced, low‐potential deazaflavin to the electron‐deficient ring systems of their substrates.