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More pieces in the promoter jigsaw: recognition of −10 regions by alternative sigma factors
Author(s) -
Busby Stephen J. W.
Publication year - 2009
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2009.06692.x
Subject(s) - biology , jigsaw , computational biology , escherichia coli , genetics , promoter , gene , mathematics education , gene expression , mathematics
Summary Two papers in this issue of Molecular Microbiology from Carol Gross and colleagues describe experiments that investigate how two alternative Escherichia coli σ proteins recognize target promoter −10 regions. A combination of genetics, biochemistry and bioinformatics is used to show that determinants in two adjacent domains of the σ proteins contact discrete sequence elements in the −10 regions.