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Modus operandi of the bacterial RNA polymerase containing the σ 54 promoter‐specificity factor
Author(s) -
Wigneshweraraj Sivaramesh,
Bose Daniel,
Burrows Patricia C.,
Joly Nicolas,
Schumacher Jörg,
Rappas Mathieu,
Pape Tillmann,
Zhang Xiaodong,
Stockley Peter,
Severinov Konstantin,
Buck Martin
Publication year - 2008
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2008.06181.x
Subject(s) - sigma factor , biology , rna polymerase , transcription (linguistics) , rna polymerase ii , polymerase , sigma , gene , genetics , microbiology and biotechnology , promoter , rna , gene expression , physics , linguistics , philosophy , quantum mechanics
Summary Bacterial sigma (σ) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative σ factor σ 54 confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the σ 54 factor makes with the bacterial transcription machinery.