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Subcellular localization of Escherichia coli osmosensory transporter ProP: focus on cardiolipin membrane domains
Author(s) -
Mileykovskaya Eugenia
Publication year - 2007
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2007.05766.x
Subject(s) - cardiolipin , biology , escherichia coli , membrane protein , biochemistry , membrane transport protein , integral membrane protein , cell membrane , peripheral membrane protein , microbiology and biotechnology , cell , phospholipid , membrane , gene
Summary The role for specific lipids in the spatial distribution of the membrane proteins and formation of the lipid‐protein membrane domains is an emerging theme in the studies of the supramolecular organization of the bacterial cell. A combination of the lipid and protein visualization techniques with manipulation of the cell lipid composition provides a useful tool for these studies. This MicroCommentary reviews the first experimental example demonstrating an involvement of the phospholipid cardiolipin in recruitment of a membrane protein (specifically H + ‐osmoprotectant symporter ProP) to the Escherichia coli cell poles. The properties of cardiolipin domains employed in creating a specific environment for structural organization and function of membrane protein complexes are also discussed.