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The novel Hha/YmoA family of nucleoid‐associated proteins: use of structural mimicry to modulate the activity of the H‐NS family of proteins
Author(s) -
Madrid Cristina,
Balsalobre Carlos,
García Jesús,
Juárez Antonio
Publication year - 2007
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2006.05497.x
Subject(s) - biology , nucleoid , gene , plasmid , genetics , horizontal gene transfer , protein family , escherichia coli , dna binding protein , virulence , microbiology and biotechnology , genome , transcription factor
Summary The Hha/YmoA family of proteins is a group of conserved, low‐molecular‐weight proteins involved in the regulation of gene expression. Studies performed in Escherichia coli , Salmonella sp. and Yersinia sp. highlight the contribution of these proteins in regulating bacterial virulence, horizontal gene transfer and cell physiology. Genes encoding such proteins are located on chromosomes and plasmids in different genera of Gram‐negative bacteria. Their mode of action is currently being analysed by studying direct binding of Hha to DNA and as a component of protein complexes with regulatory functions. Recent data on the interaction of Hha with the H‐NS family of proteins and structural information suggest a physiological role for such protein complexes in many aspects of gene regulation.