Premium
Measure for measure in the control of type III secretion hook and needle length
Author(s) -
Minamino Tohru,
Pugsley Anthony P.
Publication year - 2005
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2005.04611.x
Subject(s) - biology , secretion , flagellum , substructure , cytosol , measure (data warehouse) , microbiology and biotechnology , motility , type (biology) , type three secretion system , genetics , biochemistry , bacteria , gene , ecology , engineering , enzyme , computer science , structural engineering , database , virulence
Summary Bacterial flagella and injectisomes are supramolecular structures that are responsible for motility and for delivering toxic proteins into the cytosol of eukaryotic cells, respectively. They look very similar to each other. Both systems are called type III secretion pathways, and their components share substantial sequence similarities. One remarkable feature of the type III systems is that the length of their substructure is fairly well controlled by a secretion switching machinery, which consists of at least two proteins, a length control protein and an integral membrane secretion component. Here, we review how and why the length of these structures must be accurately controlled.