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Why is transcription coupled to translation in bacteria?
Author(s) -
Gowrishankar J.,
Harinarayanan R.
Publication year - 2004
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2004.04289.x
Subject(s) - biology , transcription (linguistics) , genetics , gene , translation (biology) , computational biology , bacteria , genome , microbiology and biotechnology , messenger rna , philosophy , linguistics
Summary Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein‐coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription–translation coupling may be viewed as one among several co‐transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to render the nascent transcript unavailable for formation of otherwise deleterious R‐loops in the genome.