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Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules?
Author(s) -
Ngô Huân M.,
Yang Mei,
Joiner Keith A.
Publication year - 2004
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2004.04056.x
Subject(s) - rhoptry , biology , biogenesis , microbiology and biotechnology , endocytic cycle , apicomplexa , organelle , exocytosis , secretory protein , secretory pathway , plasmodium (life cycle) , secretion , endoplasmic reticulum , immunology , biochemistry , endocytosis , parasite hosting , cell , plasmodium falciparum , golgi apparatus , malaria , gene , world wide web , computer science
Summary The club‐shaped rhoptries in Apicomplexan parasites are one of the most unusual secretory organelles among the eukaryotes, containing unusual lipid and protein cargo that is specialized for intracellular parasitism. Rhoptries have traditionally been viewed strictly as regulated secretory granules. We discuss in this article recent data on the cargo, function and biogenesis of rhoptries in two parasitic model systems, Toxoplasma and Plasmodium . Current findings suggest that rhoptries receive products from both biosynthetic and endocytic pathways and, therefore, they are most analogous to secretory lysosomal granules found in mammalian cells.