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Generalized approach to the regulation and integration of gene expression
Author(s) -
Oh JeongIl,
Kaplan Samuel
Publication year - 2001
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.2001.02299.x
Subject(s) - biology , gene , expression (computer science) , gene expression , computational biology , regulation of gene expression , genetics , evolutionary biology , computer science , programming language
The volume of electron flow through the cbb 3 branch of the electron transport chain and the redox state of the quinone pool generate signals that regulate photosynthesis gene expression in Rhodobacter sphaeroides . An inhibitory signal is generated at the level of the catalytic subunit of the cbb 3 cytochrome c oxidase and is transduced through the membrane‐localized PrrC polypeptide to the PrrBA two‐component activation system, which controls the expression of most of the photosynthesis genes in response to O 2 . The redox state of the quinone pool is monitored by the redox‐active AppA antirepressor protein, which determines the functional state of the PpsR repressor protein. The antirepressor/repressor system as well as a modulator of AppA function, TspO, together with FnrL and PrrA stringently control photopigment gene expression. These regulatory elements, together with spectral complex‐specific assembly factors, control the ultimate cellular levels and composition of the photosynthetic membrane.