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The sxa2 ‐dependent inactivation of the P‐factor mating pheromone in the fission yeast Schizosaccharomyces pombe
Author(s) -
Ladds Graham,
Rasmussen Erik Michael,
Young Tom,
Nielsen Olaf,
Davey John
Publication year - 1996
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1996.tb02486.x
Subject(s) - schizosaccharomyces pombe , biology , mating type , yeast , pheromone , mating , schizosaccharomyces , saccharomyces cerevisiae , mating of yeast , fission , genetics , microbiology and biotechnology , gene , physics , quantum mechanics , neutron
Summary Haploid cells of the fission yeast Schizosaccharomyces pombe exist in one of two mating types, referred to as M and P . Conjugation occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P‐factor mating pheromone and a reduction in mating efficiency. Here we demonstrate the secretion of an sxa2 ‐dependent carboxypeptidase that inactivates P‐factor by removal of the C‐terminal leucine residue.