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Identification of GroEL as a constituent of an mRNA‐protection complex in Escherichia coli
Author(s) -
Georgellis Dimitris,
Sohlberg Björn,
Hartl F. Ulrich,
Gabain Alexander
Publication year - 1995
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1995.tb02347.x
Subject(s) - groel , biology , escherichia coli , rna , messenger rna , chaperonin , chaperone (clinical) , biochemistry , microbiology and biotechnology , protein folding , gene , medicine , pathology
Summary An RNA‐binding activity has been identified in Escherichia coli that provides physical protection of RNA against ribonucleases in an ATP‐ and Mg 2+ ‐dependent manner. This binding activity is stimulated under growth conditions known to cause a decrease in the rate of mRNA decay. RNA protection is mediated by a protein complex that contains a modified form of the chaperonin GroEL as an indispensable constituent. These results suggest a new role for GroEL as an RNA chaperone.