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The mechanism of transcription termination by RNA poiymerase I
Author(s) -
Reeder Ronald H.,
Lang Walter
Publication year - 1994
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1994.tb00989.x
Subject(s) - biology , transcription (linguistics) , mechanism (biology) , rna , genetics , computational biology , microbiology and biotechnology , gene , epistemology , philosophy , linguistics
Summary Eukaryotic ribosomal gene transcription units are bordered at their 3’ends by short DNA sequences which specify site‐specific termination by RNA polymerase I (poll). Poll terminators from yeast through to mammals appear to follow similar rules: they contain a site for a sequence‐specific DNA‐binding protein; they function only in one orientation; 3’ends are formed upstream of the binding site; and 5’flanking sequences influence the position and efficiency of 3’end formation. Recent progress in understanding the mechanism of RNA chain elongation by other polymerases suggests a model for poll termination in which termination is seen as one of the several outcomes possible when a polymerase encounters a pause site.