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Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes
Author(s) -
Strohl W. R.,
Connors N. C.
Publication year - 1992
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1992.tb01995.x
Subject(s) - actinorhodin , biology , polyketide , anthraquinones , cloning (programming) , gene , polyketide synthase , streptomyces , heterologous , heterologous expression , streptomycetaceae , genetics , anthraquinone , recombinant dna , biochemistry , biosynthesis , actinomycetales , botany , bacteria , chemistry , organic chemistry , computer science , programming language
Summary This review explores the underlying biochemical and genetic principles leading to the formation of hybrid anthraquinones by recombinant anthracycline‐producing streptomycetes transformed with genes encoding the early steps in actinorhodin biosynthesis. Experiments indicate that simple aromatic polyketides are probably synthesized using very similar mechanisms, allowing for the interspecies cloning of polyketide synthase genes for the potential production of novel aromatic polyketide structures.