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The gene for the S7 ribosomal protein of Chlamydia trachomatis : characterization within the chlamydial sfr operon
Author(s) -
Wagar E. A.,
Pang M.
Publication year - 1992
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1992.tb01475.x
Subject(s) - biology , chlamydia trachomatis , operon , elongation factor , ribosomal rna , ribosomal protein , microbiology and biotechnology , gene , peptide sequence , genetics , tetracycline , virology , rna , ribosome , antibiotics , escherichia coli
Summary The prokaryotic ribosomal operon, str , contains open reading frames for the two elongation factors, elongation factor G (EF‐G) and elongation factor Tu (EF‐Tu), and ribosomal proteins 57 and S12. The DNA sequence and predicted amino acid sequence for S7 from Chlamydia trachomatis are presented and compared with homologues from other prokaryotes. Also, the relationship of the S7 gene to the open reading frames for ribosomal protein S12 and EF‐G is described. Significant amino acid homology is also noted when the amino‐terminal sequence of chlamydial EF‐G is compared with the cytoplasmic tetra‐cycline resistance factors, tetM and tetO , from streptococci and Campylobacter jejuni. Related findings and possible resistance mechanisms for the newly recognized tetracycline‐resistant clinical isolates of C. trachomatis are discussed.