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The POT1 gene for yeast peroxisomal thiolase is subject to three different mechanisms of regulation
Author(s) -
Igual J. Carlos,
GonzálezBosch Carmen,
Franco Luis,
PérezOrtin José E.
Publication year - 1992
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1992.tb01359.x
Subject(s) - biology , peroxisome , saccharomyces cerevisiae , yeast , gene , regulation of gene expression , genetics , thiolase , psychological repression , structural gene , mutant , microbiology and biotechnology , chromatin , regulator gene , gene expression
Summary Summary The Saccharomyces cerevisiae POT1 gene is, as are other yeast peroxisomal protein genes, inducible by fatty acids and repressible by glucose. We have now found that it is also induced during the stationary phase of the culture. To investigate these three regulatory circuits, we have studied the mRNA levels of regulatory mutants as well as the changes in chromatin structure upon gene activation. We conclude that the regulation of transcriptional activity in glucose repression, oleate induction, and stationary phase induction follow different molecular mechanisms. We suggest that this multiplicity of regulatory mechanisms may represent a general rule for the yeast peroxisomal protein genes.