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nov : a new genetic locus that affects the response of Escherichia coli K‐12 to novobiocin
Author(s) -
Rakonjac Jasna,
Milic Mirjana,
AjdicPredic Dragana,
Santos Diogenes,
Ivanisevic Radmila,
Savic Dragutin J.
Publication year - 1992
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1992.tb00876.x
Subject(s) - biology , novobiocin , escherichia coli , dna gyrase , locus (genetics) , genetics , complementation , gene , allele , microbiology and biotechnology , bacteria , phenotype
Summary We have identified a new gene locus (nov) affecting the resistance of Escherichia coli K‐12 to novobiocin. The gene also affects, although to a lesser extent, tolerance to another gyrase inhibitor coumermycin. Transductional and complementation analysis show that nov is located between attø80 and the osmZ (hns) genes at minute 27 of the E. coli K‐12 genetic map. In standard laboratory strains of E. coli K‐12 nov exists at least in two allelic forms.