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Secretion of a potential virulence factor, a fungal ribonucleotoxin, during human aspergillosis infections
Author(s) -
Lamy B.,
Moutaouakil M.,
Latge J.P.,
Davies J.
Publication year - 1991
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1991.tb01930.x
Subject(s) - biology , aspergillosis , virulence , secretion , pathogenesis , virulence factor , microbiology and biotechnology , ribosome , cloning (programming) , translation (biology) , antigen , gene , virology , immunology , genetics , rna , messenger rna , biochemistry , computer science , programming language
Summary We show by cloning and nucleotide sequence analysis that the 18kDa antigen found in the urine of patients suffering from aspergillosis is related to the fungal protein toxins restrictocin and mitogillin. These are inhibitors of translation which act by catalytic inactivation of eukaryotic ribosomes; they may be implicated in the pathogenesis of the disease.