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Mitochondrial gene sequences show fungal homology for Pneumocystis carinii
Author(s) -
Pixley F. J.,
Wakefield A. E.,
Banerji S.,
Hopkin J. M.
Publication year - 1991
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1991.tb00781.x
Subject(s) - biology , pneumocystis carinii , ribosomal rna , homology (biology) , gene , mitochondrial dna , protozoa , protein subunit , nadh dehydrogenase , cytochrome c oxidase , 18s ribosomal rna , microbiology and biotechnology , genetics , dna , sequence analysis , ribosomal dna , phylogenetics , virology , mitochondrion , human immunodeficiency virus (hiv) , pneumocystis jirovecii
Summary A 6.8 kjlobase fragment of mJtochondrial DNA from Pneumocystis carinii encodes for apocytochrome b, NADH dehydrogenase subunits 1, 2, 3, and 6, cytochrome oxidase subunit II, and the small subunit of ribosomal RNA. Comparative sequence analysis with a series of organisms representative of the fungal and protozoan groups shows that R carinii has, consistently, an average similarity of 60% with the fungi but only 20% with the protozoa. The data indicate homology with the fungi for this opportunistic pathogen.