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The bex locus in encapsulated Haemophilus influenzae : a chromosomal region involved in capsule polysaccharide export
Author(s) -
Kroll J. S.,
Loynds B.,
Brophy L. N.,
Moxon E. R.
Publication year - 1990
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1990.tb02034.x
Subject(s) - biology , locus (genetics) , genetics , gene , open reading frame , haemophilus influenzae , nucleic acid sequence , escherichia coli , peptide sequence , bacteria
Summary The nucleotide sequence of a 5.1 kb region in the Haemophiius influenzae type b capsulation locus has been determined and found to contain four open reading frames: bexD, bexC, bexB , and bexA. Comparison of the deduced products of bexC, bexB , and bexA to known proteins, and TnphoA mutagenesis, suggests that they form components of an ATP‐driven polysaccharide export apparatus. Furthermore, close sequence similarity between BexA and BexB and products of the kpsT and kpsM genes at the Escherichia coli K5 capsulation locus (Smith et al. , 1990 — accompanying paper) suggests that capsulation genes in these organisms may have a common ancestry.