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Processes of genome evolution reflected by base frequency differences among Serratia marcescens genes
Author(s) -
Sharp P. M.
Publication year - 1990
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1990.tb02020.x
Subject(s) - biology , serratia marcescens , gene , genetics , genome , natural selection , synonymous substitution , start codon , codon usage bias , gc content , selection (genetic algorithm) , escherichia coli , base sequence , artificial intelligence , computer science
Summary The G + C content of silent sites in codons varies greatly among Serratia marcescens genes; the value in any one gene seems to reflect a balance between mutation pressure towards high G + C content and natural selection constraining choice among synonymous codons. Interestingly, non‐coding sequences have substantially lower G + C content than silent sites thought to be under little selective constraint.