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Notes An inversion truncating the creA gene of Aspergillus niduians results in carbon catabolite derepression
Author(s) -
Arst H. N.,
Tollervey D.,
Dowzer C. E. A.,
Kelly J. M.
Publication year - 1990
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1990.tb00656.x
Subject(s) - catabolite repression , derepression , biology , gene , inversion (geology) , genetics , gene expression , paleontology , psychological repression , structural basin , mutant
Summary The creA d ‐30 mutation leading to carbon catabolite derepression in Aspergillus nidulans is a pericentric inversion, having one breakpoint within the creA gene on the left arm of chromosome I and the other breakpoint between binG and yA on the right arm. The left‐arm breakpoint alters the creA transcript. The likelihood that the inversion truncates creA centrally strengthens a previous proposal that derepression is the phenotype of loss‐of‐function mutations in creA.