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Notes The ribonucleoside diphosphate reductase gene ( nrdA ) of Escherichia coli carries a repetitive extragenic palindromic (REP) sequence in its 3'structural terminus
Author(s) -
Merino E.,
Bolivar F.
Publication year - 1989
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1989.tb00232.x
Subject(s) - palindrome , biology , gene , palindromic sequence , gene duplication , genetics , ribonucleotide reductase , escherichia coli , sequence (biology) , coding region , nucleic acid sequence , terminator (solar) , microbiology and biotechnology , genome , protein subunit , ionosphere , physics , astronomy
Summary A computer search for repeated sequences led us to identify five REP (repetitive extragenic palindromic) sequences in the 3′ ‐terminal region of the Escherichia coli ribonucleoside diphosphate reductase gene (nrdA). These REP sequences are located within a putative duplicated DNA region, the first of them being part of the carboxy‐terminal coding region of the nrdA gene. This is the first report of a REP sequence within a structural gene and also the first example of a REP sequence apparently generated by DNA duplication.