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The Yersinia yop regulon
Author(s) -
Cornelis G. R.,
Biot T.,
Rouvroit C. Lambert,
Michiels T.,
Mulder B.,
Sluiters C.,
Sory M.P.,
Bouchaute M.,
Vanooteghem J.C.
Publication year - 1989
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1989.tb00129.x
Subject(s) - regulon , operon , biology , plasmid , activator (genetics) , regulator , microbiology and biotechnology , gene , pilus , genetics , regulation of gene expression , mutant , virulence
Summary Growth of yersiniae is restricted at 37°C in the absence of calcium ions. This phenomenon correlates with the massive release of a set of proteins called Yops. Growth restriction and Yops production are governed by a 70 kb plasmid called pYV. yop genes are distributed throughout pYV and constitute a thermoactivated regulon controlled by the gene virF . The transcription activator VirF is a member of a new family of regulators including those of the arabinose and rhamnose operons as well as a regulator of enteric colonization pili. The role of calcium ions on the release of Yops remains largely unknown.