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Mammalian cell adhesion functions and cellular penetration of enteropathogenic Yersinia species
Author(s) -
Isberg R. R.
Publication year - 1989
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1989.tb00128.x
Subject(s) - biology , microbiology and biotechnology , cell adhesion , yersinia , penetration (warfare) , yersinia pseudotuberculosis , cell , bacteria , genetics , virulence , gene , operations research , engineering
Summary The entry of enteropathogenic Yersinia into cultured mammalian ceils has been studied in order to gain insight into the mechanism of bacterial penetration into host cells during infection. There exist at least three pathways for entry by Yersinia into mammalian cells, the most efficient of which is promoted by invasin, the product of the inv gene. Invasin is an outer membrane protein that attaches to a mammalian cell receptor, initiating the entry process. Several receptors that bind invasin have been identified, and each is a member of the VLA family of integrin cell adhesion molecules. The role of integrins in the entry process is discussed, as is the ability of invasin to stimulate uptake by binding to its integrin receptor.