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Antibodies to Anopheles midgut reduce vector competence for Plasmodium vivax malaria
Author(s) -
SRIKRISHNARAJ K. ALAGARATNAM,
RAMASAMY RANJAN,
RAMASAMY MANTHRI S.
Publication year - 1995
Publication title -
medical and veterinary entomology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 82
eISSN - 1365-2915
pISSN - 0269-283X
DOI - 10.1111/j.1365-2915.1995.tb00003.x
Subject(s) - midgut , biology , gametocyte , plasmodium vivax , antibody , malaria , virology , vector (molecular biology) , anopheles , immunology , plasmodium falciparum , botany , larva , biochemistry , gene , recombinant dna
Anopheles tessellatus mosquitoes ingested Plasmodium vivax gametocytes in human erythrocytes suspended in rabbit sera with and without anti‐mosquito midgut antibodies. When the mosquito bloodmeal contained anti‐midgut antibodies, fewer oocysts of P. vivax developed on the mosquito midgut and the proportion of mosquitoes becoming infected was significantly reduced. Complement inactivated serum also reduced the infection rate and load. A second bloodmeal containing anti‐midgut antibodies, given 48 or 72 h later, did not enhance the transmission‐blocking effect. IgG purified from antimidgut sera was shown to mediate the transmission‐blocking effect.