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Primary hepatocytes as targets for Hepatitis C virus replication
Author(s) -
Farquhar M. J.,
McKeating J. A.
Publication year - 2008
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2008.01051.x
Subject(s) - virology , hepatitis c virus , viral replication , virus , biology , host factors , replication (statistics) , genome , host (biology) , host factor , ns2 3 protease , genetics , gene
Summary. Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.