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Microsomal triglyceride transfer protein ( MTP ) –493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients
Author(s) -
Zampino R.,
Ingrosso D.,
DuranteMangoni E.,
Capasso R.,
Tripodi M.F.,
Restivo L.,
Zappia V.,
Ruggiero G.,
Adinolfi L. E.
Publication year - 2008
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2008.00994.x
Subject(s) - microsomal triglyceride transfer protein , genotype , steatosis , fatty liver , allele , medicine , biology , gene polymorphism , triglyceride , endocrinology , gene , cholesterol , lipoprotein , very low density lipoprotein , disease , genetics
Summary. (A) A reduced activity of microsomal triglyceride transfer protein (MTP), a key enzyme of assembly/secretion of lipoproteins, is related to HCV steatosis. Host genetic background may influence development of steatosis. The aim of the study was to investigate the association between MTP ‐493 G/T gene polymorphism, fat liver accumulation and fibrosis progression in HCV infected patients. A total of 102 naïve patients with liver biopsy proven chronic hepatitis C were evaluated for MTP ‐493 G/T gene polymorphism, HCV RNA, HCV genotype, HOMA‐IR, serum adiponectin, TNF‐α and serum lipid levels. HCV genotype 3 infected patients carrying the T allele of the MTP gene polymorphism showed higher degree of steatosis than those carrying GG genotype (3.45 ± 0.37 vs 1.30 ± 0.45, respectively; P < 0.001). MTP ‘T’ allele carriers also had higher HCV RNA serum levels ( P < 0.01) and hepatic fibrosis ( P < 0.001). Irrespective of MTP genotype, patients with HCV genotype 3 had lower levels of cholesterol, ApoB, HDL and LDL. In HCV genotype non‐3 infected patients no parameters were associated with MTP gene polymorphism. In conclusion the presence of T allele of MTP‐ 493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation.