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Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon
Author(s) -
Yurdaydın C.,
Bozkaya H.,
Önder F. O.,
Şentürk H.,
Karaaslan H.,
Akdoğan M.,
Çetinkaya H.,
Erden E.,
ErkanEsin Ö.,
Yalçın K.,
Bozdayı A. M.,
Schinazi R. F.,
Gerin J. L.,
Uzunalimoğlu Ö.,
Özden A.
Publication year - 2008
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2007.00936.x
Subject(s) - lamivudine , medicine , interferon , combination therapy , discontinuation , gastroenterology , alpha interferon , chronic hepatitis , immunology , virus
Summary. Chronic delta hepatitis is the most severe form of chronic viral hepatitis for which interferon (IFN) is the only available treatment. In 39 patients (25 were treatment‐naïve, 14 had previously used IFN), efficacy of 1‐year treatment with IFN (9 MU, t.i.w.) or lamivudine (LAM; 100 mg, q.d.) alone was compared with IFN and LAM combination (2 months of LAM to be followed by combination treatment). IFN monotherapy was given only to treatment‐naïve patients. In both treatment‐naïve and previous IFN users, end of treatment virological and biochemical responses were similar with IFN–LAM combination and superior to LAM monotherapy ( P < 0.05). Improvement in liver histology occurred more often with IFN ± LAM than with LAM alone ( P < 0.05). In treatment‐naïve patients, combination treatment was not superior to IFN monotherapy. After treatment discontinuation, virological and biochemical response rates decreased in LAM and IFN combination and IFN monotherapy. On treatment virological response at month 6 of treatment predicted sustained virological response. The results of this study suggest that addition of LAM to IFN for the treatment of delta hepatitis is of no additional value and that both treatment modalities are superior to LAM monotherapy.