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Susceptibility to active decompensated cirrhosis is associated with polymorphisms of intercellular adhesion molecule‐1 (ICAM‐1) in chronic HBV carriers
Author(s) -
Zhang X.Q.,
Hong X.J.,
Bai X.J.
Publication year - 2008
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2007.00931.x
Subject(s) - cirrhosis , hepatitis b virus , haplotype , medicine , immunology , asymptomatic carrier , icam 1 , pathogenesis , virology , genotype , virus , gene , biology , asymptomatic , cell adhesion molecule , genetics
Summary. Intercellular adhesion molecule‐1 (ICAM‐1) plays an important role in the pathogenesis of viral hepatitis B. Several inflammatory diseases are associated with distinct polymorphisms of the ICAM‐1 gene. The aims of this study were to analyse the association of ICAM‐1 polymorphisms G241R and K469E with susceptibility to active decompensated cirrhosis in chronic hepatitis B virus (HBV) carriers. The polymorphisms at codons G241R and K469E of ICAM‐1 were analysed by sequence‐specific primer polymerase chain reaction (PCR‐SSP) in 572 unrelated chronic HBV carriers and 157 unrelated healthy HBV non‐infected blood donors. There were significantly increased frequencies of R at codon 241 and E at codon 469 in patients with active decompensated cirrhosis (38.3% and 58.3%), compared with patients with chronic hepatitis B (CHB; 21.9% and 46.5%) and chronic asymptomatic HBV carriers (AsC; 12.6% and 40.3%). The frequencies of R241‐E469 haplotype and genotypes carrying at least one R241‐E469 haplotype were significantly higher in patients with active decompensated cirrhosis than those in patients with CHB (38.3% and 63.3% vs 21.9% and 36.7%), and significantly higher in patients with CHB than those in AsC (21.9% and 36.7% vs 12.6% and 23.3%). The ICAM‐1 polymorphisms at codons G241R and E469K were associated with the disease susceptibility, and susceptibility to active decompensated cirrhosis is significantly increased in chronic HBV carriers carrying at least one R241‐E469 haplotype.