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Clearance of hepatitis C virus in HIV‐infected patients with multiple chronic viral hepatitis
Author(s) -
MartínCarbonero L.,
Barreiro P.,
JiménezGalán G.,
GarcíaBerriguete R.,
Núñez M.,
Ríos P.,
GonzálezLahoz J.,
Soriano V.
Publication year - 2007
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2006.00839.x
Subject(s) - hbsag , medicine , virology , hepatitis c virus , hepatitis b virus , liver disease , viral load , antibody , immunology , viral hepatitis , hepatitis b , hepatitis c , odds ratio , viral disease , virus
Summary. Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case–control study conducted in 107 human immunodeficiency virus (HIV)‐infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)‐positive patients had negative serum HCV‐RNA while it occurred in only nine (10%) of 85 HBsAg‐negative counterparts ( P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV‐RNA and CD4 counts, being HBsAg‐positive was strongly associated with having negative serum HCV‐RNA (odds ratio: 23; 95% confidence interval: 6–59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV‐infected patients, which may influence liver disease and therapeutic decisions.