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Clinicopathological differences between hepatitis B viral genotype B‐ and C‐related resectable hepatocellular carcinoma
Author(s) -
Lin CL.,
Chen JD.,
Liu CJ.,
Lee PH.,
Chen PJ.,
Lai MY.,
Kao JH.,
Chen DS.
Publication year - 2007
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2006.00776.x
Subject(s) - hepatocellular carcinoma , genotype , cirrhosis , medicine , gastroenterology , hepatitis b virus , hepatitis b , virology , biology , gene , virus , genetics
Summary. Clinical and pathogenic differences exist between hepatitis B viral (HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular carcinoma (HCC) development than genotype B. The aim of this study was to investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectable HCC. Stored serum samples from 193 patients with resectable HBV‐related HCC were tested for HBV genotypes by a molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and 86 (45%) were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis (33% vs 51%, P = 0.01). Pathologically, genotype B patients had a higher rate of solitary tumour (94% vs 86%, P = 0.048) and more satellite nodules (22% vs 12%, P = 0.05) than genotype C patients. Our results indicate that genotype B‐related HCC is less associated with liver cirrhosis and has a higher frequency of solitary tumour as well as more satellite nodules than genotype C‐related HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV‐related HCC in patients with genotype B or C infection.