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Type‐IV Indian swine HEV infects rhesus monkeys
Author(s) -
Arankalle V. A,
Chobe L. P,
Chadha M. S
Publication year - 2006
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2006.00759.x
Subject(s) - hepatitis e virus , virology , biology , hypervariable region , genotype , seroconversion , zoonosis , antibody , virus , immunology , genetics , gene
Summary. In contrast to countries reporting zoonotic spread of hepatitis E virus (HEV), distinct genotypes circulate in humans (genotype 1) and pigs (genotype 4) from India indicating rarity of such spread. Pigs were refractory to human HEV. As rhesus is an excellent animal model for human HEV, an attempt was made to infect rhesus monkeys with swine HEV. Experimental infection of both the rhesus monkeys with swine‐HEV as evidenced by seroconversion to anti‐HEV antibodies and presence of viraemia suggests possibility of human infections or differential susceptibility. Comparison of Open Reading Frame‐2 and hypervariable regions of HEV genomes showed identity of swine and monkey‐derived HEV.