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Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy
Author(s) -
Kramvis A.,
Kew M. C.
Publication year - 2005
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.2005.00624.x
Subject(s) - genotype , biology , virology , hepatitis b virus , disease , hepatitis c virus , population , virus , antiviral therapy , phylogenetic tree , genetics , medicine , gene , chronic hepatitis , environmental health
Summary. Phylogenetic analysis has led to the classification of hepatitis B virus into eight genotypes, designated A to H. The genotypes have differences in biological properties and show heterogeneity in their global distribution. These attributes of the genotypes may account not only for differences in the prevalence of hepatitis B virus mutants in various geographic regions, but also be responsible for differences in the clinical outcome and response to antiviral treatment in different population groups.