Premium
A study of hepatitis δ virus infection in patients with acute and chronic liver disease from northern India
Author(s) -
Singh V.,
Goenka M. K.,
Bhasin D. K.,
Kochhar R.,
Singh K.
Publication year - 1995
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.1995.tb00021.x
Subject(s) - medicine , hepatocellular carcinoma , fulminant hepatitis , chronic liver disease , incidence (geometry) , antibody , fulminant , liver disease , virus , fulminant hepatic failure , viral hepatitis , disease , hepatitis b virus , gastroenterology , hepatitis , immunology , virology , liver transplantation , cirrhosis , transplantation , physics , optics
Summary. To assess the prevalence of hepatitis 8 virus (H5V) in northern India, 204 adult patients with acute and chronic liver disease who were positive for hepatitis B virus (HBV) markers were screened for anti‐H8V antibody by enzyme‐linked immunosorbent assay (ELISA). Anti‐H8V antibodies were positive in 29 (14.2%) patients. The incidence of H8V infection was higher (21.4%) in patients with chronic liver disease when compared with those with acute viral hepatitis (10.7%) (P<0.05). HδV antibodies were positive in 16.6% of patients with fulminant hepatic failure (FHF) and in 25% of cases with hepatocellular carcinoma. Co‐infections were significantly higher in acute hepatitis (80%), while super infections predominated (66.7%) in chronic liver disease ( P < 0.05). Our data show that HδV is endemic in northern India and should be considered a major health problem.