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Interferon response pathways—a paradigm for cytokine signalling?
Author(s) -
Müller M.,
Ibelgaufts H.,
Kerr I. M.
Publication year - 1994
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/j.1365-2893.1994.tb00109.x
Subject(s) - signal transduction , suppressor of cytokine signalling , biology , signalling , signalling pathways , jak stat signaling pathway , microbiology and biotechnology , cytokine , suppressor of cytokine signaling 1 , phosphorylation , transcription factor , socs3 , interferon , tyrosine phosphorylation , janus kinase , stat , computational biology , gene , tyrosine kinase , immunology , genetics , stat3 , suppressor
SUMMARY. Considerable progress has been made in the past few years elucidating the molecular mechanisms of cytokine signalling. The interferons (IFNs) have provided a singular system allowing the detailed characterization of a specific cytokine signalling pathway. Studies on the IFN signal transduction pathway have identified protein tyrosine kinases (PTKs) that phos‐phorylate signal transducers (STATs) which then bind to DNA promoter sequences and activate gene transcription. Related work has shown that JAKs and STATs are also activated in response to a variety of the cytokines. Thus the novel type of signal transduction pathway identified for the IFNs promises to be more widely utilized than anticipated.