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Multidose pharmacokinetics of orally administered florfenicol in the channel catfish ( I ctalurus punctatus )
Author(s) -
Gaunt P. S.,
Langston C.,
Wrzesinski C.,
Gao D.,
Adams P.,
Crouch L.,
Sweeney D.,
Endris R.
Publication year - 2013
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2012.01426.x
Subject(s) - florfenicol , catfish , ictalurus , pharmacokinetics , chemistry , oral administration , plasma concentration , pharmacology , chromatography , thiamphenicol , antibiotics , biology , chloramphenicol , biochemistry , fishery , fish <actinopterygii>
Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS / MS detection. After the administration of florfenicol, the mean terminal half‐life ( t 1/2 ), maximum concentration at steady‐state ( C ss (max)), time of C ss (max) ( T max ), minimal concentration at steady‐state ( C ss (min)), and V c / F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10 mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of <2.5 μg/mL.